Department of Molecular Biosciences, The Wenner-Gren Institute
Group Spetz published in Advanced Science
Group Spetz has recently published the article "A Non-Coding Oligonucleotide Recruits Cutaneous CD11b+ Cells that Inhibit Thelper Responses and Promote Tregs" in Advanced Science.
Kamal et.al. elucidated the immunoregulatory role of an oligonucleotide (ssON) that was found to recruit cutaneous immunoregulatory antigen-presenting cells (APCs) with increased immune checkpoint protein expression. Functional T-cell assays revealed that such immunoregulatory APCs inhibited T-helper cell responses and promoted CD4+FoxP3+Tregs. This study envisions the use of ssON as therapeutic for rebalancing overactive T-helper cell responses in the skin.
Created in: Biorender
To read the full article and to read more about Anna-Lena Spetz research group and reserach, follow the links below:
Skin-resident antigen-presenting cells play an important role in maintaining peripheral tolerance via immune checkpoint proteins and induction of T regulatory cells (Tregs). However, we lack knowledge on how to expand or recruit immunoregulatory cutaneous cells without causing inflammation.
We are exploring basic mechanisms regarding a group of small non-coding oligonucleotides and their therapeutic potential. We have discovered that a set of single-stranded oligonucleotides temporarily inhibit certain endocytic pathways and thereby modulate innate immune responses as well as providing anti-viral effects.
